Fastest route to attaining a green card?

If your wife has no US citizen qualifying relatives to sponsor her she will most likely need a US employer.  The most common route will be through the labor certification process.  Visas are backed up for years for those holding only bachelor's degrees.  If your wife has either a master's or at least 5 years progressive experience after the bachelor's in her profession she may qualify for the faster second preference category.  But of course she still needs a permanent job offer.