How can I sponsor my brother to work in the US?

You would need to petition for him as an employer for a work visa. The process will depend upon the type of work visa needed. A determination as to which visa would work best requires more information about the company, position offered, and your brother's education, experience and skills. Keep in mind that the job must be bona fide. You may face increased scrutiny about the position of hiring your brother. You can read more about the different work visas at http://myattorneyusa.com/work-visas.