If I am a U.S. citizen, married a Portuguese here in the US, if I file the I-130 now, will he be able to return to the US with his B1/B2?

Generally, a foreign national who has become married to a U.S. citizen will be unable to re-enter the U.S. with a B1/B2 visitor's visa or with a C1/D visa, because immigration authorities will suspect he has "immigrant intent," i.e. an intention to remain permanently in the U.S., and immigrant intent is incompatible with those types of nonimmigrant (temporary) visas. This is true regardless of whether the U.S. citizen spouse has filed a Form I-130 application. It may be possible for you and your husband to go forward now with a marriage-based adjustment of status application process, which could include obtaining an Employment Authorization Document and Advance Parole (a "travel document") for use while the adjustment of status application remains pending. It would be wise for you and your husband to consult with an immigration attorney who, after learning all of the relevant details, including your husband's immigration-related history and immigration-related goals, would be able to advise about eligibilities, options and strategies to attain those goals.