If I sign a general release agreement am I required to pay back my signing bonus which stated if i quit voluntarily that I would have to pay it back?

Assuming that you have no other defenses to your repayment obligation, and assuming the "general release agreement" to which you refer is a standard form release, your "general release" of someone else (e.g. your former employer) would not modify the obligations you owe under your employment agreement.  It is only if they release you that your repayment obligation would be forgiven.  Were the releases mutual?